Defining the Biosynthesis and Immunological Properties of Complex Bacterial Glycolipids

Grant number: DP130102763 | Funding period: 2013 - 2016

Completed

Abstract

We will study how sugar-lipids are made by industrially, agriculturally and medically important bacteria, and how they interact with the immune system. This will provide new insights into cell wall biosynthesis of importance to the biotechnology industry and identify new reagents for manipulating the immune system.

Related publications (3)

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition

JMH Cheng, L Liu, DG Pellicci, SJJ Reddiex, RN Cotton, TY Cheng, DC Young, I Van Rhijn, DB Moody, J Rossjohn, DP Fairlie, DI Godfrey, SJ Williams

2017-01-31

Mycobacterium tuberculosis produces dideoxymycobactin-838 (DDM-838), a lipopeptide that potently activates T cells upon binding to..

Quantitation in the regioselectivity of acylation of glycosyl diglycerides: total synthesis of a Streptococcus pneumoniae α-glucosyl diglyceride

MB Richardson, DGM Smith, SJ Williams

2017-01-01

The fidelity of acylation regioselectivity in the synthesis of mixed glycosyl diacylglycerols can be accurately measured by quanti..

Total syntheses of cis-cyclopropane fatty acids: Dihydromalvalic acid, dihydrosterculic acid, lactobacillic acid, and 9,10-methylenehexadecanoic acid

S Shah, JM White, SJ Williams

2014-12-14

cis-Cyclopropane fatty acids (cis-CFAs) are widespread constituents of the seed oils of subtropical plants, membrane components of..

University of Melbourne Researchers

Spencer Williams

Malcolm McConville